Objective Canine transmissible venereal sarcoma(CTVS) is a naturally occurring sexually transmitted neoplasm of the genital system in dogs.This tumor is unique in oncology because it can be applied in homotransplantation and xenotransplantation.This review was designed to describe the biological features of CTVS cells and investigate the approach of CTVS tumor model.CTVS tumor model is reliable and can be developed in various tissues which resemble well the characteristics of the tumor.It can be applied in large animals and some organs difficult to be transplanted,provides a basis for a wide range of clinical and radiological oncology researches.