Objective To establish a model of brain tumor by VX2 carcinoma implantation and observe the growth characteristics of the tumor.Methods VX2 tumor mass was implanted into the right parietal lobe brain 24 New Zealand rabbits.B-mode ultrasonography was proceeded to observe the growth and the volume of tumors.Animals were sacrificed at day 13, 17,19,21,23 and 25 after tumor implantation,respectively.Sections were cut for histopathological examination.The survival time and significant neurological alterations such as difficult feeding and hemiplegia were recorded.Results The median survival time of rabbits with implanted VX2 tumor was 24.5 days and the average was 24.8 days.The log-transformed plots of tumor volume approximate a straight line.17 days after tumor implantation,the VX2 tumors showed a brown coloration,appeared like fish and metastasized to the abdomen.The tumor cells infiltrated into the surrounding brain tissues and peri-tumor edema appeared since day 17 after tumor implantation.Conclusion Implantation of VX2 tumor into the rabbit brain is an useful model for human brain tumor research.