SARS-CoV infection of animal models
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R-332;

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    Abstract:

    The establishment of Severe Acute Respiratory Syndrome(SARS) animal models by SARS-Coronavirus (SARS-CoV) infection can promote the study of SARS etiology, pathogenesis, laboratory diagnosis, anti-SARS coronavirus (SARS-CoV) drug screening, development of vaccines, and more detailed description of SARS. That is to say, SARS-CoV infection animal model is the key-point of the study on SARS and will take an important role throughout of SARS research. There are at least four kind of non-human primates (Rhesus, Cynomolgus, African Green, and Common Marmosets) and six kind of small animal models (rat, mice, Guinea Pigs, hamster, Brandt's vole, Transgenic or Knock out), ferret and domestic cat were reported by today. Some of them have been broadly used on the evaluation of safety and efficiency of vaccines and drugs, such as BALB/c mice. Here, we reviewed the report on SARS animal models and compared them with SRAS patients. Thereafter, we concluded some technical guidelines for the establishment of SARS animal model.

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