It was confirmed by WHOthat the H5N1viruses resultedinsevere or fatal respiratory disease inthe majority of infectedpersons,indicatingthat the H5N1viruses had crossedthe species barrier without genetic reassortment with a humanin-fluenza virus.To design more effective strategies for prevention and treatment of H5N1viruses infected,in the presentstudy,we used atiger original HPAIVA/Tiger/Harbin/01/2003(H5N1)propagated by SPFembryonated hen eggs to es-tablishinfected animal model.TCID5…