The Comparison of Clinical Signs and Pathologic Changes of Avian Influenza Virus (H5N1) to BALB/c Mice
DOI:
Author:
Affiliation:

Clc Number:

S855.3;

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    To understand the mechanisms of H5N1 pathogenicity, we infected 6 to 8-week-old BALB/c mice by different routes of viral inoculation. The virus caused severe disease in mice, characterized by induced hypothermia, rapid weight loss, and high mortality by 2 days postinfection. And the main clinical signs of the animals began to recover by 4 days postinfection. The most severe and widespread lesions were observed in the organs of virus-infected mice, where received the virus firstly. Only mild lesions or no lesions were observed in spleens and brains. The principal lesions were occured in 2 days postinfection. Except kidney and heart, the lesions were recovered after 4 days postinfection.

    Reference
    Related
    Cited by
Get Citation
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:
  • Revised:
  • Adopted:
  • Online:
  • Published: