Abnormal Lipid Metabolism in Serum Disease Animal with Steroid-Induced Osteonecrosis
DOI:
Author:
Affiliation:

Clc Number:

R-332

Fund Project:

  • Article
  • |
  • Figures
  • |
  • Metrics
  • |
  • Reference
  • |
  • Related
  • |
  • Cited by
  • |
  • Materials
  • |
  • Comments
    Abstract:

    Objective To explore the pathogenesis of steroid-induced osteonecrosis in serum disease animal. Methods New Zealand rabbits were distributed into three groups randomly. Horse serum and dexamethasone sodium phosphate were used to induce osteonecrosis models in group A, dexamethasone sodium phosphate only in group B and saline in group C. To test and analyze the values of serum lipid, AST and ALT of all rabbits. Rabbits from all groups were observed by MRI to prove osteonecrosis and sacrificed to observe the histopathology of femoral head. Results Typical avascular necrosis of the femoral head happened in group A. The values of serum lipid, AST and ALT are distinctly different from those of other groups of which rabbits did not develop osteonecrosis. Conclusion Horse serum combining dexamethasone sodium phosphate can induce rabbit osteonecrosis model successfully. Vasculitis, abnormal serum lipid metabolism and liver disfunction together result in avascular necrosis of the femoral head. High dose steroid can not induce osteonecrosis in a short time.

    Reference
    Related
    Cited by
Get Citation
Share
Article Metrics
  • Abstract:
  • PDF:
  • HTML:
  • Cited by:
History
  • Received:
  • Revised:July 29,2004
  • Adopted:
  • Online:
  • Published: