Objective To establish a typical rat model with syndrome X. Method Adult male SD rats were operated on two kidneys, one-clipped to induce renal h ypertension. After operation, the rats were fed with a common diet for 4 weeks, and subsequently a high fructose diet for 4 weeks to induce syndrome X. Results The systolic blood pressure (SBP) was significantly increased a t 4 weeks after operation, but blood glucose and lipid were not changed markedly . Howevever, after feeding with high fructose diet for 4 weeks, hyperglycemia, h yperinsulinemia, insulin resistance, hypertension and hyperlipidemia occurred in the SD rats. Conclusion On the basis of renal hypertention for med by operation on kidneys, syndrome X can be induced in SD rats by high fructo se diet for 1 month. it may provide an ideal animal model for investigating insu lin resistance and accompanying cardiovascular disorders.