The mink, as a small and valuable fur-bearing animal, not only possesses significant economic value but has also gradually demonstrated immense potential as a novel experimental animal model due to its unique biological characteristics and similarities with humans in respiratory systems, immune responses, and other aspects. This paper comprehensively reviews the applied research on mink as an experimental animal model, encompassing its use in influenza virus animal infection models, COVID-19 animal models, animal behavior models, canine distemper animal models, vomiting models, enzyme digestion models, testicular degeneration models, and self-injurious behavior models. Additionally, the importance of mink animal welfare is emphasized, and the broad prospects for mink as an experimental animal model in scientific research are proposed, offering valuable insights and reference for the extensive application of mink as a novel experimental animal model in the future.