Nicotine addiction models and evaluation of animal behavior

1. China Tobacco Quality Supervision and Test Center, Key Laboratory of Tobacco Biological Effects, Joint Laboratory of Translational Neurobiology, Zhengzhou 450001, China. 2. University of Science and Technology of China, Hefei 230026. 3. Hefei Institute of Physical Sciences, Chinese Academy of Sciences, Hefei 230031

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    The large number of smokers has had a broad effect on society. Nicotine is one of the most widely concerning components of cigarette smoke. Long-term intake of nicotine can lead to nicotine dependence that affects higher brain functions, which may involve anxiety, learning and memory impairments, and abnormal decision-making. To facilitate analyzing the molecular mechanisms of nicotine dependence, it is common to establish rodent nicotinoid dependence models to better understand the physiological changes. This review summarizes and evaluates studies of the behavior in nicotine-dependent animal models to provide a reliable reference for researchers to establish rodent nicotine- dependent models for evaluation.

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  • Received:February 22,2022
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  • Online: January 19,2023
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