A Novel Model of Cerebral Ischemia/reperfusion Indu ced by Carotid Artery Negative Pressure Shunt in Rats

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    Objective To establish a new model of whole cerebral ischemia/reperfusion in rats on basis of anatomic and hemodynamic principle Methods Whole cerebral ischemia in rats was induced by clamping the bilateral common carotid arteries and drawing some blood from right common carotid artery continuously through right external carotid artery Meanwhile the drawn blood was retransfused into left femoral vein Reperfusion began after stopping drawing blood and removing the artery clamps Electroencephalograph(EEG),light microscope(LM) and electron microscope(EM) were used to assess the result of ischemia Results Compared with control group,the whole cerebral in the experimental group showed obvious ischemia changes in EEG,LM and EM Conclusion This novel model has several advantages such as the reliable whole cerebral ischemia,sufficient reperfusion,high rate of success,fit for injecting reagent through carotid artery,and is useful to the study of whole cerebral ischemia/reperfusion

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  • Revised:July 11,2000
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