Iron is the most abundant metal element in the brain, and iron homeostasis ensures normal physiological functions occur in this organ. When iron metabolism is disrupted in the brain, excess iron promotes the formation of free radicals and oxidative stress, leading to neuronal death. To fully study cerebral iron deposition diseases, animal models need to be established. This article reviews different modeling method , experimental mouse species, and iron types, and provides a reference for the establishment of brain iron deposition models.