| 王颖花,赵亚,郭文文,刘可,艾庆燕,师长宏.神经干细胞应用于 CCI 创伤性脑损伤模型修复的研究进展[J].中国实验动物学报,2022,30(6):867~872. |
| 神经干细胞应用于 CCI 创伤性脑损伤模型修复的研究进展 |
| Research progress of neural stem cells in repairing CCI traumatic brain injury model |
| 投稿时间：2022-03-22 |
| DOI：10. 3969 / j.issn.1005-4847. 2022. 06. 018 |
| 中文关键词: 创伤性脑损伤 神经干细胞 控制皮质冲击模型 内源性 外源性 |
| 英文关键词:traumatic brain injury neural stem cells cortical impact injury model endogenous exogenous |
| 基金项目: |
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| Author Name | Affiliation | | WANG Yinghua | 1.Yan’an University School of Medicine, Yan’an 716000, China. 2. Laboratory Animal Center, Air Force Military Medical University, Xi’an 710032. | | ZHAO Ya | Laboratory Animal Center, Air Force Military Medical University, Xi’an 710032 | | GUO Wenwen | 2.Laboratory Animal Center, Air Force Military Medical University, Xi’an 710032. 3. Gansu University of Traditional Chinese Medicine, Lanzhou 730030 | | LIU Ke | 2.Laboratory Animal Center, Air Force Military Medical University, Xi’an 710032. 3. Gansu University of Traditional Chinese Medicine, Lanzhou 730030 | | AI Qingyan | Yan’an University School of Medicine, Yan’an 716000, China | | SHI Changhong | Laboratory Animal Center, Air Force Military Medical University, Xi’an 710032 |
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| 中文摘要: |
| 创伤性脑损伤(TBI)作为一种严重颅脑损伤,是造成青壮年死亡和残疾的主要原因之一。 重症 TBI 患者面临严重的神经功能缺失和行为能力障碍,但目前临床上缺乏有效的治疗措施。神经干细胞(NSCs)作为中枢神经系统中的多潜能细胞,可分泌神经营养因子、分化为中枢神经及周围神经系统细胞,在 TBI 的治疗中发挥重 要作用。 动物模型研究表明,诱导内源性 NSCs 和移植外源性 NSCs 再生神经元均可改善 TBI 动物模型的颅脑损伤症状。 本文选择 TBI 模型中最精确、最稳定的控制皮质冲击(CCI)模型为研究对象,分别综述了诱导内源性 NSCs 再生神经元和移植外源性 NSCs 在 CCI 模型中的应用进展,以期为 TBI 治疗提供新的思路。 |
| 英文摘要: |
| Traumatic brain injury (TBI) is a severe craniocerebral injury and a main cause of death and disability in young adults. Patients with severe TBI exhibit severe neurological deficits and behavioral disorders, but there is no effective treatment strategy. Neural stem cells (NSCs) are multipotent cells in the central nervous system, which secrete neurotrophic factors, differentiate into central and peripheral nervous system cell types, and play an important role in the treatment of TBI. Recent studies in animal models have demonstrated that the induction of endogenous NSCs and transplantation of regenerative neurons from exogenous NSCs can improve the symptoms in TBI animal models. Among the various TBI models, the cortical impact injury model has the most promising application in research of TBI treatments because of its accuracy and easy manipulation. Thus, in this review, we focus on cortical impact injury models to summarize their progress in the induction of endogenous NSCs to regenerate neurons and transplantation of exogenous NSCs to provide a new therapeutic strategy for TBI. |
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