结直肠癌小鼠模型研究进展
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1.河南中医药大学,中医药科学院,郑州 450000; 2. 河南中医药大学第一附属医院,药学部,郑州 450000; 3. 纽约医学院,微生物与免疫学系,耳鼻喉系,纽约 10595

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Advances in mouse models of colorectal cancer
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1.Chinese Academy of Medical Sciences, Henan University of Chinese Medicine, Zhengzhou 450000, China. 2. Department of Pharmacy, the First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China. 3. Department of Microbiology and Immunology, and Department of Otolaryngology, New York Medical College and School of Medicine, New York, 10595, USA

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    摘要:

    结直肠癌是世界上最常见的恶性肿瘤之一,发病率和死亡率逐年上升且趋于年轻化。 结直肠癌小鼠模型增加我们对人类结直肠癌特征的理解及癌症预防和治疗的研究。结直肠癌小鼠模型可以分为自 发性模型、诱发性模型、移植性模型、转基因模型。 然而,没有一个模型概括了人类结直肠癌的所有特征,使 用特定的结直肠癌小鼠模型来解决特定结直肠癌的研究问题至关重要。本文结合国内外研究文献,对近 20 年不同结直肠癌小鼠模型的造模方法及优缺点的研究进展做一综述,为研究结直肠癌不同目的选择合适的小鼠模型。

    Abstract:

    Colorectal cancer is one of the most common malignant tumors worldwide, and the morbidity and mortality rate is increasing year by year with patients tending to be younger. The colorectal cancer mouse model increases our understanding of human colorectal cancer characteristics and cancer prevention and treatment. Murine models of colorectal cancer can be divided into spontaneous, induced, transplanted tumor, and transgenic models. However, none recapitulate all the characteristics of human colorectal cancer. The use of a specific mouse colorectal cancer model to address specific colorectal cancer research issues is critical. This paper has examined research literature both domestic and foreign to provide a review of the research progress of different mouse models of colorectal carcinoma over the past 20 years. The aim is to establish a suitable mouse model for the study of colorectal cancer.

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苗晋鑫,宋韶鹤,李秀敏.结直肠癌小鼠模型研究进展[J].中国实验动物学报,2020,28(2):0.

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  • 收稿日期:2019-09-25
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  • 在线发布日期: 2020-04-29
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