肾纤维化动物模型特点与研究进展
作者:
作者单位:

(1. 上海中医药大学附属曙光医院肝病研究所,上海 201203; 2. 上海市中医临床重点实验室,上海 201203)

作者简介:

通讯作者:

中图分类号:

基金项目:

“重大新药创制”科技重大专项(No. 2018ZX09201001 -001 -006)


Research progress of animal models of renal fibrosis and their characteristics
Author:
Affiliation:

(1. Institute of Liver Diseases, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. 2. Shanghai Clinical Key Laboratory of Traditional Chinese Medicine, Shanghai 201203)

Fund Project:

National Science and Technology on New Drug Creation and Development (No. 2018ZX09201001 -001 -006)

  • 摘要
  • |
  • 图/表
  • |
  • 访问统计
  • |
  • 参考文献
  • |
  • 相似文献
  • |
  • 引证文献
  • |
  • 资源附件
  • |
  • 文章评论
    摘要:

    肾纤维化为慢性肾病发展至终末期肾衰所必经的共同病理路径,病理改变包括肾间质纤维化和肾小球硬化?肾纤维化的理想动物模型对慢性肾病发病机制的研究及其治疗药物的研发等存在现实意义?目前,肾纤维化动物模型包括药物或毒物诱导?手术模型以及基因敲除等多种模型,不同动物模型肾功能?肾组织病理等方面各具特点,尚无法完全模拟人类慢性肾疾病,这提示慢性肾疾病发病的复杂性,对于其病理机制认识与防治具有重要意义?

    Abstract:

    Renal fibrosis is a common pathological pathway of chronic kidney diseases that leads to end?stage renal failure. The pathological changes include glomerulosclerosis and renal interstitial fibrosis. Ideal animal models for the study of pathologic mechanisms and drug development of chronic kidney disease are of great significance. At present, the method of establishment of animal models include drug or toxin induction, surgical models and gene knockout, etc. Different animal models have various characteristics of renal function and pathology, but can not completely simulate human chronic kidney disease, suggesting the complexity of chronic kidney diseases. So the preparation and research of the animal models is important for understanding the pathological mechanisms, prevention and treatment of renal fibrosis.

    参考文献
    相似文献
    引证文献
引用本文

马园园,刘成海,陶艳艳.肾纤维化动物模型特点与研究进展[J].中国实验动物学报,2018,26(3):398~403.

复制
分享
文章指标
  • 点击次数:
  • 下载次数:
  • HTML阅读次数:
  • 引用次数:
历史
  • 收稿日期:2017-12-25
  • 最后修改日期:
  • 录用日期:
  • 在线发布日期: 2018-07-20
  • 出版日期:
征稿啦 |“科技伦理前沿谈”征文通知
关闭